Created in 1997, the MOSIM conference provides a forum for exchange between researchers, teachers and industrialists in the field of modeling, optimization and simulation systems. MOSIM’16 is the 11th edition of the conference. The guiding theme is “Technological innovation in the service of systems: Challenges and Opportunities”. Recent advances in information technology and telecommunications and combined big data decisions to the new paradigms in industrial and service sectors present challenges to policymakers and researchers and force them to adapt existing methodologies and tools that are inadequate in this new context. These technological innovations also represent an extraordinary opportunity for the development of new original methodologies in the field of modeling, optimization and simulation. This 11th edition is an opportunity to promote the results of the theoretical and / or methodological but also allow presentations describing practical cases related to the chosen theme and other areas of research related to the conference.